Fig. 6.
Effect of anti–TNF-α neutralizing antibody on BFU-E colony formation.
Exogenously added mouse antihuman TNF-α neutralizing antibody in short-term culture of BMMCs at a dose of 1.8 μg/mL increased significantly the number of BFU-Es in RA patients studied prior to cA2 treatment but not in the patients studied after treatment. Bars represent the mean BFU-E number (± SEM) obtained by 106BMMCs from RA patients before (n = 4) or after (n = 3) cA2 treatment. Comparison between treated and untreated with neutralizing antibody cultures was performed using the Student t test for paired samples.
