Inhibition of FGF-2–induced corneal neovascularization by VE-cadherin mAbs.

Hydron pellets containing 50 ng of hrFGF-2 and 1 μg of either one of VE-cadherin mAbs or control IgG were surgically inserted into the mouse corneal stroma adjacent to the temporal limbus. The area of corneal angiogenesis was evaluated as described in the “Materials and methods” section. Eyes implanted with pellets containing BV14 or BV13 mAbs showed a reduction of vascularization of 64% and 72%, respectively, when compared with nonimmune rat IgG–treated group. Data are means ± SEM (n = 6) of a representative experiment out of 3 performed.