Fig. 4.
Effect of 311m on proliferation of GM colonies of normal bone marrow.
The highly effective Fe chelator and antiproliferative agent, 311m, has similar activity to the clinically used antitumor agent cisplatin but far less activity than doxorubicin at inhibiting the growth of normal GM stem cell colonies from human bone marrow. Normal bone marrow stem cells were incubated for 14 days at 37°C with the agents (0.005-0.4 μM), and the colonies were then counted. Results are from a typical experiment.
