The relationship between the antiproliferative activity of the chelators using SK-N-MC neuroepithelioma cells (IC₅₀values) and their lipophilicity (calculated log P values).

Log P_calc values were estimated by the procedures of Broto et al,46 Ghose and Crippen,47 and Viswanadhan et al48 using the program Chem Draw (v. 4.5, 1997), and the results were then averaged (Table 2). Note that all average log P_calc values were plotted (Table 2) except for chelators ST and N2mT, which had IC₅₀ values greater than 12.5 μM and thus could not be graphed.