Effects of the chelators on iron-mediated oxygen radical production as judged by ascorbate oxidation and benzoate hydroxylation.

The effects of EDTA, 311m, Triapine, and the most cytotoxic NT analogues (NT and N4mT) on (A) the Fe(III)-induced oxidation of ascorbate and (B) the Fe(II)-induced hydroxylation of benzoate. Ascorbate oxidation and benzoate hydroxylation were assessed as described in “Materials and methods.” The results are the mean ± SEM of 3 experiments.