Fig. 2.
Fig. 2. Evidence of donor specific tolerance by a mechanism of clonal deletion after IUHSCTx. / (A) Results of mixed lymphocyte reaction (MLR) in chimeric mice after IUHSCTx at 4 weeks of age. Chimeric animals do not respond to host or donor antigen stimulation but respond normally to third-party antigen consistent with donor-specific tolerance. Stimulator splenocytes are on the x-axis. *** P < 0.001. (B) Skin graft survival in chimeric recipients. (C) Efficient deletion of donor-host–specific VβTCR in chimeric mice by direct antigen presentation after IUHSCTx. *** P < 0.001 chimeric mice versus B6 control; # P < 0.05 chimeric mice versus Balb/c control. (D) Partial deletion of host-donor–specific VβTCR by indirect antigen presentation in SWR→Balb/c chimeras after IUHSCTx; *** P < 0.001.

Evidence of donor specific tolerance by a mechanism of clonal deletion after IUHSCTx.

(A) Results of mixed lymphocyte reaction (MLR) in chimeric mice after IUHSCTx at 4 weeks of age. Chimeric animals do not respond to host or donor antigen stimulation but respond normally to third-party antigen consistent with donor-specific tolerance. Stimulator splenocytes are on the x-axis. *** P < 0.001. (B) Skin graft survival in chimeric recipients. (C) Efficient deletion of donor-host–specific VβTCR in chimeric mice by direct antigen presentation after IUHSCTx. *** P < 0.001 chimeric mice versus B6 control; # P < 0.05 chimeric mice versus Balb/c control. (D) Partial deletion of host-donor–specific VβTCR by indirect antigen presentation in SWR→Balb/c chimeras after IUHSCTx; *** P < 0.001.

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