Fig. 1.
Overview of the human folate metabolic pathway.
S-adenosylmethionine (SAM); S-adenosylhomocysteine (SAH); dihydrofolate (DHF); dihydrofolate reductase (DHFR); tetrahydrofolate (THF); serine hydroxymethyltransferase (SHMT); 5,10-methylenetetrahydrofolate (5,10-methyleneTHF); 5,10-methylenetetrahydrofolate reductase (MTHFR); 5-methyltetrahydrofolate (5-methylTHF); 10-formyltetrahydrofolate (10-formylTHF); methionine synthase (MS); thymidylate synthase (TS); deoxythymidine monophosphate (dTMP); and deoxyuridine monophosphate (dUMP).