Q690P pedigree.

Age (A, years), ferritin (F, μg/L), transferrin saturation (S, %), and TfR2 Q690P and HFE H63D mutation status for the Portuguese family. “+” indicates the presence of the mutant allele, and “−” indicates its absence. The mother was heterozygous for both TfR2 Q690P and HFE H63D. Abnormal results are indicated in bold type. Values listed are those of the initial assessment for each patient.