Fig. 3.
![Fig. 3. Inhibition of CML progenitors increases with longer exposure to imatinib mesylate. / CFC frequency for CML CD34+ cells, normalized to frequency for cells not exposed to imatinib mesylate, is plotted as a function of exposure time. Data graphed are for 1 μM (- - ♦ - -]), 2 μM (—● - -), and 5 μM (—▾—) imatinib mesylate and shown as the mean ± SEM for replicate experiments (24 hours, n = 7; and 48-96 hours, n = 5). Progenitor frequency is significantly suppressed as exposure time increased from 24 to 96 hours (3 asterisks, P < .001; 2 asterisks,P < .01).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/10/10.1182_blood.v99.10.3792/6/h81022549003.jpeg?Expires=1743282730&Signature=gKB-1Vlro-8wHNyOL~JhJubxScfAfWD~AolSzadykL4GaLPt8aHBjg24wNOn-qb9ldrnZ0IkR6RHr~CikvxDPY1fdokXG4tJqHPeRmf7ocqGMKo3Z0ny-gyXcPtz6Yi7iMOJ5J0Br2LLE5UBCkZA1JwBVfB6B9z0t8I~2P0gW9OLrY~1zFuSrVr3GHscGL9OwKGoS~Gpg4LW4~VkxL7zkTwwEndr6esFLFdf0APyIJstNq3PoGwHuJ-G-KO0DJstzEWDycV5pSdpV76gxgtysN4JhBl4OquDY-AVCjz1nLT--NMR7iavbBNF6TnDeOgkFI7SGNEtqFXosvl2CJn9Yg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of CML progenitors increases with longer exposure to imatinib mesylate.
CFC frequency for CML CD34+ cells, normalized to frequency for cells not exposed to imatinib mesylate, is plotted as a function of exposure time. Data graphed are for 1 μM (- - ♦ - -]), 2 μM (—● - -), and 5 μM (—▾—) imatinib mesylate and shown as the mean ± SEM for replicate experiments (24 hours, n = 7; and 48-96 hours, n = 5). Progenitor frequency is significantly suppressed as exposure time increased from 24 to 96 hours (3 asterisks, P < .001; 2 asterisks,P < .01).
