Inhibitory effect of BMSCs on T-lymphocyte proliferation induced by allogeneic PBLs, DCs, or PHA.

Seven-day mixed cultures were performed with (black bars) or without (white bars) BMSCs. Data are expressed as mean ± SD of triplicates of 6 separate experiments. The stimulation index (SI) was calculated by using the following formula: proliferation of T lymphocytes incubated with cellular or humoral stimuli with or without BMSCs/proliferation of T lymphocytes alone. *Statistically significant (P = .004, at least) when compared with MLRs performed in the presence of BMSCs (Student t test for paired data).