BMSC-induced inhibition of T-lymphocyte proliferation is reversible.

Suppression of T-cell proliferation by BMSCs (A) is restored if T cells are recovered after a 7-day culture period and restimulated by DCs, PHA, or IL-2 in the absence of BMSCs (B). The data are expressed as mean ± SD of triplicates of 3 separate experiments. *Statistically significant when compared with MLRs performed in the presence of BMSCs (Student t test for paired data).