Killing of B-LCLs derived from leukemic patients by normal allogeneic or autologous NK cells.

(A) The same normal NK cell population reported in Figure 3 was assessed for cytotoxicity against 4 different B-LCLs derived from the same 4 representative patients. (B) B-LCLs were assessed for susceptibility to killing by autologous AML-NK cells. In both cases the cytolytic assays were performed either in the absence (black bars) or in the presence (white bars) of anti-HLA class I mAb. The E/T ratio was 12:1. This experiment is representative of 3 independent assays.