Inhibition of anti-HLA immunity in alloimmune SCID mice.
Ability of (A) F(ab′)2 fragments or (B) intact IgG molecules to affect anti-HLA immunity in alloimmune SCID mice. The results of inhibition are expressed as the percent of baseline (100%) anti-HLA reactivity, that is, calculated from the median channel fluorescence values of each SCID mouse serum at each week after administration of proteins derived from commercial IVIg (○), the sera of men (■), or the sera of multiparous women (●), compared with the preadministration reactivity. The stars indicate significance (★:P < .05; ★★: P < .01) between data points (means ± SD) obtained using proteins derived from commercial IVIg versus the sera of multiparous women. The N values of each group of treated mice are as shown. Control mice that received no treatment with intact IgG or F(ab′)2 fragments are shown in panel A (▵).
