Relative expansion and contraction of EBV lytic and latent epitope-specific CD8⁺ T-cell populations after resolution of AIM.

PBMCs were isolated from patients with AIM (acute) and 12 months after the resolution of symptoms (chronic). Cells were stained for CD8 and HLA class 1 tetramers specific for lytic (RAK) and latent (FLR, QAK) epitopes of EBV. Histograms show the 2-color staining characteristics of cells that were first gated on forward and side scatter. The percentage of cells in each quadrant is indicated. Results are representative of those from at least 10 different persons investigated.