β-Catenin cleavage in response to apoptotic stimuli.

Time-dependent β-catenin cleavage in Jurkat cells in response to anti-Fas (100 ng/mL), staurosporine (1 μM), etoposide (100 μM), and TRAIL (100 ng/mL). After incubation for the time indicated, whole cell lysates were prepared using CSK buffer and β-catenin expression was determined by Western blot analysis. β-Catenin and degradative intermediates of β-catenin (closed and open triangles, respectively) are indicated.