Relationship between the ex vivo and in vitro VWF binding to collagen and the VWF occupancy.

The ex vivo data are the mean data measured at the different time points in the 3 different dosage studies shown in Tables1 and 2 (●) and the in vitro data were obtained by adding known concentrations of mAb 82D6A3 to undiluted baboon plasma and measuring VWF occupancy and collagen binding (○). Data are the mean of 2 determinations in duplicate.