Competitive advantage for murine hematopoiesis over porcine hematopoiesis in NOD/SCID-Tg mice.

Data are shown for porcine chimerism in porcine BM recipients with (○, n = 4) or without (●, n = 4, 1 mouse died 99 days after porcine BMT) subsequent injection of NOD/SCID-Tg mouse BMCs. (A) Percentages of antipig pan-tissue mAb-positive cells in recipient WBCs at 1 week before (6 weeks after porcine BMT), and weeks 2, 5, 8, and 12 after NOD/SCID-Tg mouse BMT. (B) Levels of porcine chimerism in recipient BM at week 12 after NOD/SCID-Tg mouse BMT. Percentages of antipig pan-tissue mAb⁺ (total), myeloid/SWC3 (74-22-15⁺), and c-kit⁺ (stained by pig SCF) cells are shown. Each symbol represents an individual animal.