Fig. 5.
Concentration response curves for agonist-induced platelet aggregation and secretion.
Platelet aggregation was measured as described previously. Aspirin-treated [3H]serotonin-loaded platelets were stimulated with varying concentrations of (A) SFLLRN, (B) AYPGKF, or (C) thrombin. Platelet aggregation (solid line) and secretion (broken line) were measured as described in “Materials and methods.” The maximum response was taken as 100%, and the remaining data were normalized to this value. The data (mean ± SE) are from at least 3 independent experiments using platelets from different donors.