Fig. 9.
CEP-701 prolongs survival in Balb/c mice injected with BaF3/ITD cells.
Four groups of 10-week-old Balb/c mice (15 mice/group) were injected on day 1 with 2 × 106 BaF3/ITD cells. Subcutaneous injections of CEP-701 at 10 mg/kg every 12 hours, 20 mg/kg every 12 hours, 10 mg/kg every 8 hours, or vehicle control every 12 hours, were begun on day 1. Mice were monitored daily for survival. Moribund mice were euthanized. Percent survival is plotted on the y-axis, with days following BaF3/ITD cell injection indicated on the x-axis. Pwas calculated using a 2-tailed t test and is valid for each of the 3 treatment groups individually comparing median survival with that of the vehicle control group.
