Patterns of FISH probes used in this study.

(A,B) The correct localization of the pool of probes to chromosomes 11 and 14, respectively. (C) A plasma cell without evidence of a t(11;14)(q13;q32). There are 2 pairs of discrete red and green signals and no fusion signals. The plasma cells can be easily distinguished by the intense blue fluorescence of the cytoplasm. (D) An abnormal plasma cell with 2 fusion signals resulting from the comigration of probes and indicative of a t(11;14)(q13;q32). (E) Another abnormal cell (Leica DMRXA). Original magnification, × 63. DAPI counterstain in panels A and B. cIg-FISH on panels C-E.