The DNA enzyme reduced the JMML cell mass in vivo.

Enumeration of JMML cells in recipient mouse femoral bone marrows revealed that continuous treatment with the active DNA enzyme decreased the leukemic cell mass and reduced the mortality. Values are means and SEM based on mice undergoing transplantation with JMML cells from 8 patients (3 mice per JMML patient). *P < .05; **P < .01 when compared with mice treated with DOTAP only.