Fig. 6.
Fig. 6. Time course of serum cytokine concentrations after injection of 2 × 109 transducing units of either the first-generation vector fgAdhFIX or the HD vector AdFTC/hFIX. / Serum IL-6 (A) and TNF-α (B) concentrations. Serum samples were collected 12 hours before and 6 hours, 18 hours, 36 hours, and 96 hours after viral injection. ■ = 2 × 109 transducing units fgAdhFIX; ▵ = 2 × 109 transducing units AdFTC/hFIX; ♦ = vehicle (PBS); ● = 1 × 1010 transducing units of the first-generation adenoviral vector Ad.hAAT expressing alpha 1–antitrypsin under the control of the Rous sarcoma virus promoter. Mean ± SD is shown.

Time course of serum cytokine concentrations after injection of 2 × 109 transducing units of either the first-generation vector fgAdhFIX or the HD vector AdFTC/hFIX.

Serum IL-6 (A) and TNF-α (B) concentrations. Serum samples were collected 12 hours before and 6 hours, 18 hours, 36 hours, and 96 hours after viral injection. ■ = 2 × 109 transducing units fgAdhFIX; ▵ = 2 × 109 transducing units AdFTC/hFIX; ♦ = vehicle (PBS); ● = 1 × 1010 transducing units of the first-generation adenoviral vector Ad.hAAT expressing alpha 1–antitrypsin under the control of the Rous sarcoma virus promoter. Mean ± SD is shown.

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