Myeloid cells from mice with SBS and CML-like leukemia express Tel-Abl protein.

Protein lysates from PB leukocytes and spleen cells (S) from mice withTEL-ABL–induced SBS, TEL-ABL–induced CML-like disease, and p210 BCR-ABL–induced CML-like disease were analyzed by Western blotting with anti-Abl (top panel) and antiphosphotyrosine (bottom panel) antibodies. Extracts from splenocytes from a normal Balb/c mouse (Balb/c) and from Ba-F3 cells expressing c-Abl or Tel-Abl were included as controls. The figure shows a composite of 2 blotting studies done simultaneously under identical conditions.