Fig. 3.
Effect of NF-κB inhibition on expression of apoptosis inhibitors.
NF-κB inhibition decreases expression of apoptosis inhibitors. Immunoblotting analysis for apoptosis regulators in cell lysates of MM.1S cells treated with SN50 (20 μM) for 0, 4, 8, or 16 hours. SN50 rapidly decreased protein expression of Bcl-2, A1, XIAP, cIAP-1, cIAP-2, and survivin. In contrast, Mcl-1 and BclxL protein levels were not changed. Moreover, SN50 up-regulated the expression of the proapoptotic Bax protein.
