Quantitative expression analysis of 17 cell cycle and apoptosis-related genes in B-CLL and MCL.
Relative expression measured by RQ-PCR, normalized to 4 housekeeping genes and control expression data by bar plots, where the height of the bars represents the relative gene expression for individual patient and control samples on a logarithmic scale. Horizontal lines crossing the bars indicate the computed limits for significant up-regulation and down-regulation determined by the maximum χ2 square analysis (Table 2). Each bar represents one patient or control sample. The single MCL without the t(11;14)(q13;q32) translocation is highlighted by an asterisk. Because the RQ-PCR analyses were repeated for the genes BCL2, CCND1, CCND3,CDK4, TP53, RB1, MYC,SELL, TFDP2, and ETV5, a horizontal line in the respective bar shows the resultant value of the second analysis.
