KGF pretreatment increases post-BMT thymopoiesis.
(A) Mean absolute thymocyte numbers ± SD from non-BMT control (n = 5) and either PBS- or KGF-treated congenic BMT recipients (n = 9-10 per group) conditioned with 3 doses of radiation (650, 1000, and 1400 cGy) were analyzed at day 28 after BMT. Gray bar, non-BMT control; diagonally hatched bar, donor-derived thymocytes; black bar, host-derived thymocytes.P1 = non-BMT control versus PBS;P2 = non-BMT control versus KGF;P3 = PBS versus KGF. (B) Mean absolute thymocyte numbers ± SD from either PBS- (vertical hatched bar) or KGF-treated (cross-hatched bar) allogeneic BMT recipients (n = 8 per group), conditioned with either 900 cGy irradiation alone or cyclophosphamide plus 750 cGy, were analyzed at day 28 after BMT.
