Identification of the adhesion molecules mediating the interaction between activated platelets and activated endothelium.

Translocation of TRAP-activated platelets was increased 2.5 times in comparison to that of resting platelets in the in vitro flow chamber and was largely mediated by endothelial VWF-platelet GPIbα interactions and platelet P-selectin–P-selectin glycoprotein ligand 1 interactions. Platelet GPIIb/IIIa contributed for 20% to platelet adhesion (*P < .05, **P < .001).