Fig. 8.
Fig. 8. Effect of CO on cell cycle progression and cyclin expression in vascular SMCs. / (A) Effect of CO on the distribution of SMCs in the cell cycle. Cells were treated with serum (5%) and SnPP (20 μM) for 24 hours in the presence and absence of CO (200 ppm). Results are means ± SEM of 4 separate experiments. *Statistically significant effect of CO. (B) Effect of CO on the expression of cyclins A, E, and D1 protein. Cells were treated with serum (5%) and SnPP (20 μM) for 24 hours in the presence and absence of CO (200 ppm). Similar findings were observed in 3 separate experiments. (C) Effect of CO on the expression of cyclin A mRNA. Cells were treated with serum (0%-10%) and SnPP (20 μM) for 24 hours in the presence and absence of CO (200 ppm). Similar findings were observed in 3 separate experiments.

Effect of CO on cell cycle progression and cyclin expression in vascular SMCs.

(A) Effect of CO on the distribution of SMCs in the cell cycle. Cells were treated with serum (5%) and SnPP (20 μM) for 24 hours in the presence and absence of CO (200 ppm). Results are means ± SEM of 4 separate experiments. *Statistically significant effect of CO. (B) Effect of CO on the expression of cyclins A, E, and D1 protein. Cells were treated with serum (5%) and SnPP (20 μM) for 24 hours in the presence and absence of CO (200 ppm). Similar findings were observed in 3 separate experiments. (C) Effect of CO on the expression of cyclin A mRNA. Cells were treated with serum (0%-10%) and SnPP (20 μM) for 24 hours in the presence and absence of CO (200 ppm). Similar findings were observed in 3 separate experiments.

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