Red and white blood cell counts in

Fancc^−/− andFancc^+/+ mice treated with MMC and cytokines. RBC counts (A), WBC counts (B), and survival curves (C) of Fancc^−/− and wild-type mice receiving either MMC alone (Fancc^+/+, ■;Fancc^−/−, ▪) or in combination with G-CSF (Fancc^−/−, ♦), erythropoietin (Fancc^−/−, *), or G-CSF with erythropoietin (Fancc^+/+, ○;Fancc^−/−, ●). Each point represents the mean ± SEM of 2 to 4 mice. The absence of SEM bars indicates that values were too low to appear in the graph. Significant differences between Fancc^−/− without cytokines compared toFancc^−/− treated with cytokines: *,P < .01; †, P < .05. RBC at week 1: EPO,P < .01; G-CSF and G-CSF + EPO,P < .05. RBC at week 2: G-CSF, P < .01; EPO and G-CSF + EPO, P < .05. WBC at week 1:P < .05. WBC at week 2: G-CSF + EPO,P < .01.