Relationship between p53 dysfunction, CD38 expression, and IgV_H mutation.

(A) 2-D plot. Patients with functionally intact p53 are represented by open diamonds, those with type A p53 dysfunction by closed squares, and those with type B p53 dysfunction by closed triangles. Lines have been drawn to indicate the cutoff values used to define CLL subgroups on the basis of IgV_H mutation and CD38 expression. (B) Venn diagram showing the relationship.