Fig. 7.
Reduced sensitivity of Smad5−/− HPP-CFCs to TGF-β1 inhibition.
The inhibitory effect of TGF-β1, added to HPP-CFC assay at final concentrations of 0.03, 0.1, 0.3, and 2 ng/mL, is shown. These results are from a representative experiment; 4 other independent experiments demonstrated similar results.