Fig. 4.
59Fe absorption in mice with reduced iron stores or accelerated erythropoiesis.
Iron deficiency was induced by maintaining weanling mice (4 weeks of age) on iron-deficient diets for 7 weeks. Control mice of all genotypes were 10 to 11 weeks of age. Erythropoiesis was induced either by treating mice with phenylhydrazine (PHZ) or by phlebotomy.59Fe was administered by gavage and percentage administered iron absorbed was determined as described in “Materials and methods.” Open bars show results for wild-type mice (+/+); black bars, Hfe knockout mice (−/−; shaded bars, C282Y knockin (Y/Y). Error bars represent SEM. The number of animals in each group is shown above columns.
