Fig. 6.
Fig. 6. A cleavage of a caspase-3 substrate (PhiPhiLux) is observed in proplatelet-displaying MKs. / Mobilized blood CD34+ cells were cultured as in Figure 1. A proplatelet-displaying MK at day 12 shows a diffuse staining pattern with PhiPhiLux (A, green fluorescence), predominantly in the perinuclear area. Labeling in the proplatelet is weak. The VWF (red fluorescence) is present in the whole cytoplasm, including proplatelets (B). (C): Nucleus stained with DAPI. Original magnification, × 630.

A cleavage of a caspase-3 substrate (PhiPhiLux) is observed in proplatelet-displaying MKs.

Mobilized blood CD34+ cells were cultured as in Figure 1. A proplatelet-displaying MK at day 12 shows a diffuse staining pattern with PhiPhiLux (A, green fluorescence), predominantly in the perinuclear area. Labeling in the proplatelet is weak. The VWF (red fluorescence) is present in the whole cytoplasm, including proplatelets (B). (C): Nucleus stained with DAPI. Original magnification, × 630.

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