Effect of CD18 RARE and proximal promoterets sites on RA responsiveness of a heterologous promoter.

The CD18 RARE and proximal promoter ets sites function independently to confer RA responsiveness to a heterologous promoter. (A) Diagrammatic representation of the TK/luc promoter, RARβ-RARE-TK/luc, RARE1-TK/luc, RARE2-TK/luc,ets-1–TK/luc, ets-3–TK/luc, andets-4–TK/luc. (B) The indicated promoter constructs were stably transfected into U937 cells, and responsiveness to RA was measured, as described in the legend to Figure 3. All data represent the mean and standard error of at least 3 independent clones, each tested in at least triplicate.