Fig. 5.
Fig. 5. Consensus sequence for the cleavage site of propeptide from mature VWF by the processing enzyme PACE-furin, characterized by a functionally important Lys (K) at position −2 and Arg (R) at position −4 upstream of the cleavage site (R-S). / The Cys2527Thr mutation falls at position −4 and changes the Arg to a Cys.

Consensus sequence for the cleavage site of propeptide from mature VWF by the processing enzyme PACE-furin, characterized by a functionally important Lys (K) at position −2 and Arg (R) at position −4 upstream of the cleavage site (R-S).

The Cys2527Thr mutation falls at position −4 and changes the Arg to a Cys.

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