American Society of Hematology

Fig. 4.

$Fig. 4. Firm adhesion, but not rolling, of Tyr AG490–treated lymphocytes is impaired in PLN HEVs. / The behavior of fluorescently labeled control- and Tyr AG490–treated lymphocytes was directly observed in the PLN microcirculation as described in “Materials and methods.” (A) Rolling fraction of lymphocytes in HEVs. Rolling fractions of control and Tyr AG490–treated lymphocytes obtained in identical HEVs are connected by a line. There is no significant difference between both samples (P = .33). (B) Sticking fraction of lymphocytes in HEVs. Sticking fractions of control and Tyr AG490 lymphocytes obtained in identical HEVs are connected by a line. Firm adhesion is significantly reduced in Tyr AG490–treated lymphocytes (P < .001) (n = 6 animals/11 venules analyzed).$

Firm adhesion, but not rolling, of Tyr AG490–treated lymphocytes is impaired in PLN HEVs.

The behavior of fluorescently labeled control- and Tyr AG490–treated lymphocytes was directly observed in the PLN microcirculation as described in “Materials and methods.” (A) Rolling fraction of lymphocytes in HEVs. Rolling fractions of control and Tyr AG490–treated lymphocytes obtained in identical HEVs are connected by a line. There is no significant difference between both samples (P = .33). (B) Sticking fraction of lymphocytes in HEVs. Sticking fractions of control and Tyr AG490 lymphocytes obtained in identical HEVs are connected by a line. Firm adhesion is significantly reduced in Tyr AG490–treated lymphocytes (P < .001) (n = 6 animals/11 venules analyzed).

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