Real-time ASO PCR results. Blood clonal myeloma tumor B-cell levels measured by real-time ASO PCR (see “Study design”) in 6 MM patients immunized with the autologous Id during 30 weeks of follow-up. Arrows indicate immunization times. Three patients received IL-12 alone (MM-1, MM-3, and MM-6) and 3 patients received IL-12 plus GM-CSF (MM-2, MM-4, and MM-5) as adjuvants. The number of IgH copies detected at initiation of vaccination was set to 100%. The values during follow-up are given as percent of the initial sample. Mean ± SEM for 3 measurements are shown.