Figure 3.
Contractile effects of oxyHb and oxyMb on GSNO- and SNOmetHb-dependent, but not SNOoxyHb-dependent, vessel relaxation. Contractile effects of oxyHb (10 μM, ▪) or oxyMb (10 μM, ▦) on GSNO-, SNOoxyHb-, and SNOmetHb-mediated relaxation of rat thoracic aorta were determined as indicated in Figure 2. Contractile effects are expressed as the percentage reversal of the maximal contraction obtained with phenylephrine and L-NAME. Data represent mean ± SEM, n = 3. All experiments were conducted in KH buffer, equilibrated with 95% O2, 5% CO2,at 37°C.
