Figure 6.
Effect of SOD on relaxation stimulated by SNOoxyHb, SNOmetHb, and GSNO at low oxygen tensions. Vessels were exposed to low oxygen by perfusion of baths with 5% CO2, 95% N2 for 15 minutes prior to addition of relaxation stimuli. The effects of SOD (100 U/mL) on concentration-dependent relaxation stimulated by SNOoxyHb (0-500 nM SNO), SNOmetHb (0-500 nM SNO), or GSNO (0-100 nM) were then measured as described in the legend to Figure 4. Data represent the fold decreases in EC50 for relaxation observed in the presence of SOD. Data represent means ± SEM (n = 3-5). *P < .2 versus SNOoxyHb. **P < .001 versus SNOoxyHb group.
