Increased erythrocyte osmotic fragility and decreased activity of the plasmatic coagulation in transgenic animals. Osmotic fragility of erythrocytes from transgenic mice (B) was markedly increased from 4 months onward compared with wild-type controls (A). Prolongation of the activated partial thromboplastin time (C) and the thrombin clotting time (D) revealed a decreased activity of the plasmatic coagulation; wt indicates wild-type; tg, transgenic; OD, optical density. *P < .01, #P < .001 compared with age-matched wild type controls.