TC-A induces apoptosis in B-CLL cells and normal B cells. B-CLL cells of 48 B-CLL patients (□) and B cells of 31 healthy donors (▦) were left untreated or treated with 1 μM or 2.5 μM TC-A for 24 hours. The increase in phosphatidylserine exposure was determined by flow cytometry. Results are shown as the differences of TC-A—induced apoptosis minus spontaneous apoptosis. Box plots represent median values and 50% of the data, and whiskers represent the interquartile ranges.