TC-A induces the processing of multiple cellular targets in B-CLL cells. EHEB cells were left untreated or treated with 0.5, 1, or 2.5 μM TC-A alone (left) or in combination with zVAD-fmk (20 μM; right) for 24 hours. Subsequently, cell lysates were prepared and immunoblot analyses for Bax, Bcl-2, caspase-3 (casp3), -8, -9, and PARP performed. As internal loading control for equal amounts of protein, α-tubulin was detected. Representative results from at least 2 independent experiments are presented.