Fig. 1.
The HERV-K gene and the t(8;19) breakpoint resulting in HERV-K-FGFR1.
(A) Genomic structure of the HERV-K gene. Double arrow indicates the t(8;19) breakpoint; number ranges in brackets, the exon positions in the LLNLR-245B6 sequence; numbers separated by →, exons in the LOC113386 sequence; ▨, 5′ LTR fragment; ▧, 3′ LTR fragment; ▥, LINE; ░, ORF ENV-Like; number ranges in parentheses: positions of repeats and ORF in the LOC113 386 mRNA. (B) Nucleotide and amino acid sequences around the t(8;19) breakpoint for the resulting fusion product HERV-K–FGFR1.