Dissolution of fibrin clots containing myosin in a flow circuit. Cylindrical fibrin clot containing 10 nM plasmin was prepared as described in “Materials and methods” and buffer was perfused through its central longitudinal channel with an initial shear rate of 400 s^–1. The attenuance of the soluble protein products released in the fluid phase was monitored at 280 nm. The median of triplicate experiments is shown as solid line (6 μM fibrin) and dotted line (6 μM fibrin containing 2 μM myosin). The arrows indicate the clot-disassembly time.