Figure 3.
Reconstitution of CD8+ T cells specific for lytic or latent EBV epitopes is delayed in recipients of SCT from MUD pretreated with ATG, compared with recipients of SCT from an HLA-matched related donor (MRD) not treated with ATG. For this analysis, data on CD8+ T cells specific for any of the 3 lytic epitopes (left panels) or any of the 9 latent epitopes (right panels) studied were pooled (see “Patients, materials, and methods”). The normal ranges were defined as described in the legend to Figure 2 after the same procedure. Differences between recipients of MRD-SCT (top panels) and MUD-SCT (bottom panels) reached significance for CD8+ T cells specific for lytic EBV epitopes at 2 months after SCT (P = .008 using the Wilcoxon test). See the legend to Figure 1 for further details.