Vaccination with stressed apoptotic 12B1-D1 cells induces long-term, specific antitumor immunity.

Naive and surviving mice were rechallenged 56 or 80 days later with 2 × 10⁴ (LD₁₀₀) 12B1-D1 cells (A), or 10³ (LD₁₀₀) parental 12B1 cells (B), or 10⁶ (LD₁₀₀) A20 cells (C) in the groin. (In 12B1 or 12B1-D1 rechallenged mice, P < .05 from day 15 onward; in A20 rechallenged mice, P = NS; n = 8-16 surviving and 8 naive mice, pooled data from 2 experiments.)