Alignment of the immediate upstream promoter sequences of the human and murineEPCRgenes. The nucleotide sequences spanning –601 to +3 bp of the hEPCR gene and spanning –550 to +1 bp of the mEPCR gene were aligned to identify regions of sequence similarity. All numbering is relative to the A of the ATG initiation codons. Stars indicate aligned nucleotides; dashes indicate gaps in the alignment. Predicted transcription factor binding sites are underlined in the human (h) sequence. Transcription factor binding sites identified in the murine (m) promoter10 are highlighted in bold. The previously identified transcription start site of the human gene7 is indicated by the arrow.