Mapping of DNaseI hypersensitive sites around thehEPCRgene. (A) DNaseI hypersensitivity sites were mapped in HUVEC, HeLa, U937, and HepG2 cells (lanes 2-5). Lane 1 indicates DNA undigested with DNaseI. The approximate band size in kilobase (kb) is indicated on the left of the figure. The location of sites in relation to the hEPCR gene is indicated on the right. (B) Map of the BamHI fragment encompassing the hEPCR gene. Exons 1 to 4 of the hEPCR gene are indicated as rectangles, and the identified hypersensitive sites are indicated (above the figure) by the arrows. The locations of the probes used in this analysis are indicated as gray boxes below the figure.