Microarray data analysis showing relative gene expression levels of the B-CLL subset resistant to irradiation-induced apoptosis. (A) Comparative data analyses and ratios between resistant (R) and sensitive (S) B-CLL samples both expressing p53wt from first (R1/S1) and from second (R2/S2) microarray analysis revealed that 5 transcripts were up-regulated (red boxes) and 10 transcripts were down-regulated (green boxes) in a constitutive manner in resistant B-CLL samples. (B) Comparisons between all resistant (R′) versus sensitive (S′) samples in 2 microarrays at 3 hours after irradiation only, expressing both p53wt (R′1/S′1, R′2/S′2), and p53mt (Rm′/S′1), showed that 36 transcripts were down-regulated and 13 transcripts were up-regulated in all resistant B-CLL samples, regardless of p53 status. (C) Comparisons between resistant samples only, before and after irradiation (R′1/R1, R′2/R2 Rm′/Rm1), showed modified expression of 58 transcripts (31 up- and 27 down-regulated). The green (down-regulation) to red (up-regulation) color scale indicates the relative values (fold change, FC) of gene expression levels.