Figure 2.
Effect of antibodies to α4β1 and c-Kit on directed migration in mast cells. Antibodies to α4β1 and c-Kit inhibit directed (haptotactic) migration in mast cells. Migration assays were performed with the use of mast cells in the presence or absence of SCF after preincubating the cells with 20 μg/mL anti-α4, anti–c-Kit, or appropriate isotype control antibodies. Cell migration is expressed as in Figure 1. Shown are the means ± SEMs of 40 different fields from 2 independent experiments performed in duplicate.*P < .05 for isotype control versus anti-α4 or anti–c-Kit antibody.
